Second-seeded ISU is aiming for its seventh MVC Softball Championship title.
Whichever team wins the series will claim the crown and the top-seed in next weekend's MVC Tournament.
The three-game set starts with a noon doubleheader on Saturday, before concluding with a single noon game on Sunday.
ISU will go for its fourth-straight MVC series win this weekend in Chicago.
Wednesday's 5 p.m., match up will mark the Redbirds' 27th and final non-conference game.
WJBC Redbird Recap - Northern Illinois. vs. ISU
ISU Softball Regional Highlights
WJBC Recap - Softball MVC Championship Game
The Redbirds fell to DePaul,3-1, in the annual Strike Out Cancer game at Marian Kneer Stadium.
The Redbirds fell to Northern Iowa, 9-3, on Senior Day at Marian Kneer Stadium.
The Redbirds knocked off Missouri State, 9-1 in six innings, to take the series, 2-1.
The Redbirds and Bears split a doubleheader, April 6. ISU won game one, 1-0, before dropping game two, 7-4.